joho Posted May 29, 2006 Report Share Posted May 29, 2006 Will diamorphine hydrochloride react with sodium hydroxide to give diamorphine free base? Yes or No. Not a drug dealer! Its an exam question!:) Quote Link to comment Share on other sites More sharing options...
Mercedes Benzene Posted May 29, 2006 Report Share Posted May 29, 2006 Nope. I'm pretty sure it would not.:) Quote Link to comment Share on other sites More sharing options...
Mercedes Benzene Posted May 29, 2006 Report Share Posted May 29, 2006 ACUTALLY: I want to change my above answer. :) My mistake.... I am fairly certain that it WOULD produce the free base form by reacting it with sodium hydroxide.Sorry.....:( Quote Link to comment Share on other sites More sharing options...
joho Posted May 29, 2006 Author Report Share Posted May 29, 2006 ACUTALLY: I want to change my above answer. :) My mistake.... I am fairly certain that it WOULD produce the free base form by reacting it with sodium hydroxide.Sorry.....:) Thanks, but can you give me an idea how? An equation maybe or point me somewhere I can find one? Quote Link to comment Share on other sites More sharing options...
UncleAl Posted May 29, 2006 Report Share Posted May 29, 2006 An amine hydrochloride will obviously be neutralized by sodium hydroxide solution. Look at the pKa values. Kinetics of reaction can depend on steric hindrance and electronics, e.g., 2,2,6,6-tetramethylpiperidine and 1,8-bis(dimethylamino)naphthlene. Will NaOH do evil to other parts of your molecule? Quote Link to comment Share on other sites More sharing options...
Kayra Posted May 29, 2006 Report Share Posted May 29, 2006 OK UncleAl, now your just making up words. :) Quote Link to comment Share on other sites More sharing options...
UncleAl Posted May 30, 2006 Report Share Posted May 30, 2006 OK UncleAl, now your just making up words.;)http://www.mazepath.com/uncleal/sunshine.jpg Tormod and Kayra 2 Quote Link to comment Share on other sites More sharing options...
TheBigDog Posted May 30, 2006 Report Share Posted May 30, 2006 http://www.mazepath.com/uncleal/sunshine.jpgI am not sure what is more impressive; the flexibility or the depth. Bill Quote Link to comment Share on other sites More sharing options...
Kayra Posted May 30, 2006 Report Share Posted May 30, 2006 http://www.mazepath.com/uncleal/sunshine.jpg Ooch.Impressive penetration. Did I mention that they were very GOOD words? Quote Link to comment Share on other sites More sharing options...
joho Posted June 2, 2006 Author Report Share Posted June 2, 2006 An amine hydrochloride will obviously be neutralized by sodium hydroxide solution. Look at the pKa values. Kinetics of reaction can depend on steric hindrance and electronics, e.g., 2,2,6,6-tetramethylpiperidine and 1,8-bis(dimethylamino)naphthlene. Will NaOH do evil to other parts of your molecule? Mmmhhm. Yep. Yep. I see. Thanks. Haven't got a clue what you mean but thanks! Like the pic - hope thats not you!::) Quote Link to comment Share on other sites More sharing options...
Kayra Posted June 2, 2006 Report Share Posted June 2, 2006 Mmmhhm. Yep. Yep. I see. Thanks. Haven't got a clue what you mean but thanks! Like the pic - hope thats not you!::hihi: I find that if you re-read old UncleAl's posts about 3-2,000 times they actually start to make sense. At least I see I am not alone. Quote Link to comment Share on other sites More sharing options...
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