mynah Posted October 31, 2008 Author Report Share Posted October 31, 2008 Don't worry, they keep on telling us... Janusz Paweska, head of the special pathology unit at the South African National Institute for Communicable Diseases, at work in Johannesburg. Quote Link to comment Share on other sites More sharing options...
mynah Posted April 25, 2009 Author Report Share Posted April 25, 2009 This could be the next big one... Coming soon to an airport near you? Quote Link to comment Share on other sites More sharing options...
mynah Posted April 25, 2009 Author Report Share Posted April 25, 2009 Latest news: Breaking news: WHO on high alert This is beginning to look even more like the big one. It has many characteristics not seen in the SARS and avian flu outbreaks in Asia, and has many of the hallmarks of a pandemic: High mortality rate especially among young adults, novel genetic composition, is spread from person to person, and is spreading from town to town... In addition, Americans may take notice of the fact that it has already crossed their borders... Quote Link to comment Share on other sites More sharing options...
Cedars Posted April 25, 2009 Report Share Posted April 25, 2009 Latest news: Breaking news: WHO on high alert This is beginning to look even more like the big one. It has many characteristics not seen in the SARS and avian flu outbreaks in Asia, and has many of the hallmarks of a pandemic: High mortality rate especially among young adults, novel genetic composition, is spread from person to person, and is spreading from town to town... In addition, Americans may take notice of the fact that it has already crossed their borders... High mortality rate? No one knows what the mortality rate is yet. The epicenter seems to be mexico and they are still shipping samples to labs to determine which strain infected who. Last I read, 1/2 of the tested specimens were of this H1N1 variant, the others were other types of flu and all known (as I understood the articles). What I dont know is if these samples were all fatalities, some fatalities or no fatalities. The novel genetic combo is very interesting. One unconfirmed source stated the swine flu's in this are european swine and N. American swine, and implied that this was not asian in origin. Note this info for the torontosun link below. Another piece which is fodder for conspiracy theorists is the first USA case being discovered/indentified at a Naval hospital which specializes in outbreak study. (somewhere on msnbc). Then I found this article via a different website (note the date, late February 2009):Baxter: Product contained live bird flu virus | Canada | News | Toronto Sun "The contamination incident, which is being investigated by the four European countries, came to light when the subcontractor in the Czech Republic inoculated ferrets with the product and they died. Ferrets shouldn’t die from exposure to human H3N2 flu viruses." I have no idea if ferrets exposed to H1N1 die from it. I also have no idea if Baxter has operations in mexico. Someone posted info about a canadian microbe research (canadian CDC type place) confirming the contaminated samples referred to in the torontosun article. So I searched this canadian site for info on the contaminated H5N1. I found nothing but there were a bunch of articles about some strains of H1N1 being documented by this place for drug resistance. I do find two different strains of swine flu locking in with the same type of avian flu and apparently the same human genetic combination and showing up in the same country at the same time to be suspect. Now if this was a contamination issue, rather than a wild strain suddenly appearing, it would make sense for the initial government/cdc type statements made yesterday about it being "too late for containment, its already out there", which really surprised me. Quote Link to comment Share on other sites More sharing options...
mynah Posted April 27, 2009 Author Report Share Posted April 27, 2009 From the New York Times: US declares public health emergency Too early to say how serious it is - or will be - but best to be prepared. Strangely enough, the Spanish flu pandemic appears to have started with relatively mild cases that attracted little attention for several months before turning really virulent. (Then again, having a world war on at the same time could be a bit attention-diverting...) Quote Link to comment Share on other sites More sharing options...
Michaelangelica Posted June 10, 2009 Report Share Posted June 10, 2009 PRESS RELEASEMEDIA RELEASE: 09 Jun 2009 How germs meet their opposites - a mystery revealed in real time Sophisticated microscope technology has made it possible for Australian and American scientists to record previously unknown interactions between two classes of immune cell right at the beginning of the 'antigen transport chain', the apex of the immune response. Using intravital two-photon microscopy, which allows light to penetrate deep into tissue and processes to be observed as they happen in a live animal, Dr Tri Phan from Sydney's Garvan Institute of Medical Research, while working with Dr Jason Cyster from the University of California San Francisco, captured an intriguing interaction between macrophages and B cells. Their findings, describing the atypical and highly specialised 'subcapsular sinus (SCS) macrophages' and their interaction with antibody producing B cells, are published online in the prestigious international journal, Nature Immunology. The lymph system, an exquisitely designed drainage and filtering network, forms the core of the body's immune system. When a bacterium, or other invader, breaches the skin it is carried in lymph vessels to the nearest lymph node to be destroyed by macrophages or dendritic cells (scavenging immune cells), unless first captured by them along the way. As well as employing a 'seek out and destroy' approach, our immune system has evolved a second more sophisticated function. It stores a memory of invaders. To generate that memory, B cells need to become activated. "We were interested in what drives B cell activation, and where it occurs," said Tri. "To become activated, B cells must get to know the enemy. They must 'see' the shape of bacterial or viral antigens - their three-dimensional surface structures - so that they can create antibodies to help destroy the invader in the present, as well as form 'memory B cells' which will attack similar invaders in the future." "To get to know antigens this way, B cells need to meet them in their native state. Until now, we have not been able to figure out how antigen actually gets to a B cell without first being broken down, or destroyed, by a macrophage or dendritic cell." Lymph vessels around the body drain into channels in and around lymph nodes known as 'sinuses'. These sinuses are lined with endothelial cells and macrophages that appear to form a barrier against antigen. The largest sinus, the one enclosing the lymph node capsule, is known as the subcapsular sinus. Tri explained that SCS macrophages are embedded within the sinus lining, with their 'heads' capturing antigen from newly arriving lymph on one side, and their 'tails' delivering it to B cells on the other side. "What we've witnessed through the microscope shows intact antigen being passed through the subcapsular sinus. SCS macrophages behave almost like miniature conveyor belts, passing antigen to B cells waiting at the other side. All this happens within minutes of the antigen's arrival in a lymph node." "This is a new and very important finding. While other groups have noted the presence of unusual macrophages in the subcapsular sinus, and have also observed the presence of B cells nearby, their relationship to one another has been unclear." "Each time we characterise, or describe, an essential element of the immune system, it takes us a step further towards being able to control disease and infection." With the ability to see whole processes in action that two-photon microscopy gives them, medical researchers will be able to build up a picture of the way the immune system functions much more rapidly than would have been conceivable even a decade ago. NOTES TO EDITORS Two photon microscopy Since the mid-1990s, fluorescent proteins have been used as tags, or markers, helping cell biologists track the movements (under the microscope) of their favourite molecules within cells. Fluorescence is excitation of an electron inside a molecule to a high energy state (the electron moves from one orbit to the next). When it relaxes and changes to its lower energy state, it releases that energy as light. Until now, scientists have been limited to some extent by the proteins available to them, most of which are excited by shorter wavelengths of light - Green Fluorescent Protein (GFP), for example, fluoresces when stimulated by waves of around 488 nanometers. This is fine for tracking proteins inside cells in culture, but not good for tracking events in living tissue. That is because short wavelengths easily become absorbed or scattered by molecules in their path, so do not pass easily through tissue and bone. Ideally, you would like an organ to be 'optically transparent'. Within the visible range, it's obviously not transparent because it doesn't let light through. At the longer light wavelengths, however, in the near-infrared and infrared ranges, tissue becomes more optically transparent. So light with those longer wavelengths will penetrate much deeper without getting scattered or absorbed. A month ago, the team that won the Nobel Prize for developing the GFP published the news that they have developed a protein that glows at wavelengths around 700 nanometers, in the infrared range. This protein will vastly expand the 'reach' of a microscope. Conventional microscopy uses single photon excitation. The advantage of two-photon microscopy is that you expand your 'reach' by exciting the electron with two photons of half the energy. By making the photons half the energy, you double their wavelength and ability to penetrate tissue, because energy is inversely proportional to wavelength. In two-photon microscopy, an electron is excited by two photons that arrive in very rapid succession. The first photon bumps up the electron halfway, the second photon bumps it up the rest of the way. Recent advances in technology have led to the production of lasers that can consistently produce photons that are so densely packed together that they are only 10-15 seconds apart, allowing 2 photon excitation. Using GFP and Single photon excitation, a confocal microscope will allow you to see to a depth of around 50 microns. Using GFP with two-photon microscopy, you get much deeper penetration, allowing intra-vital studies such as the one described in this media release. Combining two-photon microscopy with infrared proteins will allow scientists to see even deeper into tissue. Limits of penetration up to now have been about 500 microns - or roughly .5 millimetre. The new infrared proteins will expand that severalfold. ABOUT GARVANThe Garvan Institute of Medical Research was founded in 1963. Initially a research department of St Vincent's Hospital in Sydney, it is now one of Australia's largest medical research institutions with nearly 500 scientists, students and support staff. Garvan's main research programs are: Cancer, Diabetes & Obesity, Immunology and Inflammation, Osteoporosis and Bone Biology, and Neuroscience. The Garvan's mission is to make significant contributions to medical science that will change the directions of science and medicine and have major impacts on human health. The outcome of Garvan's discoveries is the development of better methods of diagnosis, treatment, and ultimately, prevention of disease. All media enquiries should be directed to: Alison HeatherScience Communications Manager+61 2 9980 1224+61 434 071 326a.heather "at" garvan.org.au Garvan Profile: Dr Robert BrinkResearch Group: B Cell Immunobiology Back Quote Link to comment Share on other sites More sharing options...
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