Marijuana and psychosis. Interesting topic. I've known patients who go in for psychiatric evaluations after not having been sober for up to 11 years. It is next to impossible to tell whether their symptoms are there because of their biology or because of what they are ingesting into their body. Do they have a depressive affect because that is how they are, or because that is what 11 years of smoking weed is doing to them? The recommendation for them is to always abstain from marijuana use for about two weeks and then follow up to see if their symptoms have resolved or not. In terms of psychosis, what psychosis do you mean? The denotation of psychosis in a medical dictionary is simply: "A mental and behavioral disorder causing gross distortion or disorganization of a person's mental capacity, affective response, and capacity to recognize reality, communicate, and relate to others to the degree of interfering with the person's capacity to cope with the ordinary demands of everyday life." - Stedman's Medical Dictionary. Psychosis is divided into two major classifications given their origin. 1) Those associated with organic brain syndromes i.e: Korsakoff Syndrome**. 2) Those less clearly organic and having some functional component i.e: The schizophrenias, bipolar disorders. **Korsakoff Syndrome is associated with alcoholics and often coexists with Wernicke Syndrome. So, which psychosis does the original poster mean when asking if marijuana is it's cure or it's cause (which I think is what they were trying to get at). In my experience, marijuana use has often been the cause of such psychoses as bipolar affective disorders and schizophrenias. I don't think I have yet to see marijuana used as a stimulant to uplift someone's mood. Though I suppose I am an unlikely contributor as I have never engaged in the act of smoking marijuana and don't feel that I ever will. The destruction it brings upon the body and mind is not something I would ever find myself willingly doing - I enjoy my body and all my senses and don't feel that I should ever want any of them depressed. As I am at work, I don't have the time to cite any articles to back up what is now simply my opinion but given the logistics - one does not prescribe a depressant to one who is depressed, I would have to say that marijuana is not a cure for a psychosis. Though again, it's up to interpretation and anyone who can find articles in support of my opinion or in opposition. Cheers Halo