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Geert Vanden Bossches Covid prediction


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I guess you have heard of him.

Basically as i understand he says it was insanity to mass inject people with a vaxx that is not sterilizing during a pandemic.

Because we left the virus to mutate so that resistant variants will have an advantage and become dominant.

He also expects more dangerous variants. As far as i understand he mean non neutralizing antibodies take over when the virus is resistant to neutralizing abs.

The non neutralizing abs protect against severe disease but eventually there may be variants that overcome this immune pressure.

Usually dangerous variants can´t spread well but what about now when so many got the shots?

So he recommends governments implement large antiviral drug campaigns in heavily vaxxed countries.

 

What do you think of his thoughts? The first parts about the danger of mass vaxxing this way seems obvious to me.

An interview with Bossche from April.

https://www.voiceforscienceandsolidarity.org/videos-and-interviews/deadlier-variants-dr-geert-vanden-bossche-on-what-to-expect-in-the-near-future-and-why

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"Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein

The deployment of vaccines against SARS-CoV-2 brings the question of mutational escape from antibody prophylaxis to the forefront. Rapid evolutionary evasion of neutralizing antibodies (nAbs) poses a number of threats to biomedical interventions aimed at bringing the virus under control, namely the risk of reduced vaccinal efficacy over time as resistant variants continue to emerge (which may or may not be rectifiable with annual vaccine updates), the risk of waning effectiveness of natural immunity as a result of evasion of common nAbs, and the risk of antibody-dependent enhancement (ADE)."

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0250780

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"COVID vaccines can't keep up with new Omicron subvariants

New subvariants of the Omicron strain of the COVID-19 virus "appear to be even more immune-resistant than the original," Axios reported Wednesday.

The original Omicron strain was known as BA.1, but that's old hat by now. All the cool kids are getting BA.4, or even BA.5. Unfortunately, while the virus has moved on, vaccine makers are stuck in the past."

https://news.yahoo.com/covid-vaccines-cant-keep-omicron-145138040.html

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Posted (edited)

From Bossches paper. Why he believe the mass vaxx will lead to more dangerous variants for the vaxxed.

Natural selection of new, O-glycosylated variants, which I have predicted to rapidly emerge (https://www.voiceforscienceandsolidarity.org/scientific-blog/predictions-gvb-on-evolution-c-19-pandemic),would allow to overcome binding of both, potentially infection-inhibiting (i.e., neutralizing) Abs directed at theimmuno dominant receptor-binding domain (RBD) and potentially ‘trans infection’-inhibiting (note 2) (i.e., virulence-mitigating) Abs directed at the conserved antigenic site within the N-terminal domain of S protein (S-NTD). Consequently,O-glycosylation of the S-RBD would overcome population-level immune pressure that results from boosting of vaccine-primed Abs directed at conserved NTD-specific epitopes that cross-protect against severe disease. This is because NTD-associated ‘trans infection’-inhibiting (i.e., virulence mitigating) epitopes will be shielded against their corresponding Abs by the O-glycosites inserted at the predicted O-glycosylation sites of the new variants (New covariants). At the same time, these O-glycosites would also shield RBD-associated infection-inhibiting (i.e., neutralizing) epitopes against their corresponding Abs. Natural selection of the O-glycosylated Newco variants would, therefore, enable SC-2 to effectively counter the growing virus-neutralizing and virulence-mitigating capacity of a highly vaccine-experienced population that is exposed to Omicron, and thereby relieve the pressure on the viral life cycle.

The more Omicron expands in prevalence and the more frequently vaccinees get re-exposed and fall victim to breakthrough infections, the higher the prevalence of both elevated virulence-mitigating anti-S Abs will become.  The higher this prevalence and the higher the anti-S Ab titers, the higher the site occupancy of the predicted O-glycosylation sites will need to be for Newco variants to resist the trans infection-inhibiting immune response of Omicron-infected vaccinees. This is because more densely O-glycosylated variants will more effectively prevent mitigation of viral virulence. Given the population-level immune pressure caused by the exposure of highly vaccinated populations to the highly infectious Omicron, Newco variants will primarily rely on glycosite instead of amino acid mutations in their RBD to gain the required fitness advantage in a landscape of increasing population-level immune pressure on S-NTD.

This already explains why the upcoming Newco variants are likely to evolve to a super variant that is not only highly infectious but also highly virulent and fully resistant to C-19 vaccines, including those that have been adapted to the spike protein of the circulating variant. This is why the authors of this paper are desperately wrong in thinking that tailoring the vaccines to the polypeptide sequence of S on the dominantly circulating variant would have a beneficial effect on the outcome of the mass vaccination program. On the contrary, usage of so-called ‘updated’ vaccines to continue this program will only aggravate the outcome due to further boosting of anti-NTD Ab titers.

Conclusion:In the absence of large scale antiviral prophylaxis, the vicious circle of steadily increasing immune pressure causing steadily rising infection rates will ultimately drive highly vaccinated populations to promote the expansion of a super variant that will likely be featured by full resistance to potentially neutralizing epitopes (due to lack of immunogenicity of these epitopes) combined with a high propensity to cause Ab-dependent enhancement of infection (ADEI; facilitated by the infection-enhancing Abs) and a high propensity for causing ADEI-mediated Ab-dependent enhancement of disease (ADED).This is how the evolutionary dynamics of the virus will unfold and how the end station of this misguided mass vaccination program will look.

Edited by NV722
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Basically if i understand Bossche the problem is the narrow protection from the shot + immune imprinting. So when the virus is resistant infections in the vaxxed lead to a boost of non neutralizing abs. Those abs prevent severe disease but eventually the virus will likely mutate to variants that will overcome that immune pressure. More dangerous variants. Guess they can spread easier because the distance between vaxxed is shorter.

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https://www.medrxiv.org/content/10.1101/2022.04.18.22271936v1

Igor explain what it means.

https://igorchudov.substack.com/p/moderna-knew-vaccinated-people-will?s=r


"This study looked at two sides of the Moderna Phase 3 vaccine trial: the vaccinated group and the control group. They looked at unvaccinated people having Covid, versus vaccinated people having so called “break-through Covid infections”.

Skipping some details, our natural, unvaccinated immunity learns to recognize the “spikes” (S-protein), the “nucleocapsid” (N-Protein) and other pieces of the virus, and develops antibodies and immune memory reacting to all of those.

This multifaceted memory also provides broader protection against “variants”.

In contrast, vaccination with any existing Covid vaccine, floods our cells with only S-protein (the “spike protein”) from a virus that only existed around January 2020.

The difference between the vaccinated and the unvaccinated is FIVE TIMES, which is huge. The unvaccinated are five times more likely than the vaccinated to develop broad immunity including N antibodies.

for those vaccinated persons whose breakthrough infection occurred after the second dose, (illness detected on Day 29), their ability to develop N antibodies was 13 TIMES worse than that of the unvaccinated.

This inability to obtain broader natural immunity is the reason for endless covids: a covid infection in the vaccinated does not result in lasting immunity and acts similarly to an almost-worthless booster shot. A “breakthrough infection” adds a large number of temporary S-antibodies to the obsolete Wuhan virus. Whereas, the unvaccinated obtain numerous antibodies to all sorts of facets (epitopes) of the virus that infected them."

 

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