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How do we really know anything for sure? What I mean is, in life we all try to at least get a rough glimpse of the "biggest picture", as in what is the general nature of reality, truth, and existence.. where is our own place in the universe and in the world and the grand scheme of things.. and also how all this relates to each of us, how it matters and affects our individual subjective inner lives and worlds within a world existence.. We want to know the bigger picture, to get the general direction correct so everything else that we believe, think, feel, act, behave and do in life isn't wasted or do for nothing.. But yet how do we know anything for certain? How do we actually know when we have arrived at that formation or discover of the "largest most general abstract model of life and existence?" How can we know things that we do not know? And does it matter or are the distinctions even significant if we will never know them in this lifetime? But what if perchance they are accidentally discovered? What if we bump into these epiphanies when not even looking for them and this fractures and shatters the worldviews that we already deeply hold most dear to us and have tethered to them our most real and cherished identities and emotional attachments? Like a guy who wants to find a good girl for himself.. He thinks he's found the one, but what if someone "better" latter comes along and he's already settled down with her? By better I don't just mean physical attractiveness, but a personal and interpersonal qualitative difference in being.. Or someone who thinks he's already figured out what life is all about.. One who has experienced the full range of emotional experiences and felt the entire spectrum of human consciousness and canonical and or higher order qualia.. and formulated his own subjective opinions on what "life is really all about" and which first hand emotional experiences (such as a certain type of beauty, love, lust, pleasure, happiness, comfort, etc) is the "best" way to spend his life..... BUT.... then later on discovers by accident a whole new "world"/"realm"/"domain" of experiences and emotional states that he didn't even know existed! What then? How do we know when we have "reached the top"? Why is there no ultimate supremum "set of all sets"? Can we know anything for sure? Is the universe in its entirety a closed or open system? Ultimately at this level do such distinctions even matter? Why does existence itself seem like an impossible contradiction? Why do humans have the compulsion to know the best states of existence and to touch the infinite?

Hi everyone I'm new here, just seeking so physilogical answers.