Hello All. Hoping that there's anyone who knows a little something about this topic. Perhaps some people in here have conducted research on immunostimulators. This isn't my field of expertise but I need to learn more about a few things so any advice or guidance will be really appreciated.
1. I need to know a little more about how specific or non specific Cytotoxic CD8 T-Cell receptors are. For example if your body has a latent pathogen such as latent TB or toxoplasma cysts the immune system is no longer trying to fight them as they're effectively hiding from it. Upon detection of a new pathogen such as a HIV infection the immune system will be activated. It will release, amongst many immune cells, Cytotoxic CD8 T-Cells. The T-Cells will recognise HIV as its antigen. Will the immune system release Cytotoxic CD8 T-Cells which are only capable of fighting HIV infected cells as this is the pathogen which has currently stimulated it? Or will the CD8 T-Cells which are released upon detection of HIV also be capable of killing cells infected by other pathogens including latent infections if they come into contact with them? Also can this vary? Are there instances where more generalised or a more diverse spread of Cytotoxic CD8 T-Cells are released and other instances where more specialised Cytotoxic CD8 T-Cells are released? If so what are some factors which determine this?
2. What effect does purposely stimulating the immune system by exposure to an allergen have on the production and release of Cytotoxic CD8 T-Cells and what’s the effect (if any) of this increased activation of the immune system on internal pathogens in general and also specifically on toxoplasma cysts?
3. What’s the effect (if any) of pure isolated oral histidine consumption on histamine levels, the subsequent effect on the immune system and on the production and release of Cytotoxic CD8 T-Cells?
4. Besides perfecting the diet and lifestyle such as correcting Vitamin A deficiencies, what are some ways to purposely induce an immune response and increase production and release of Cytotoxic CD8 T-Cells for a limited time such as for 1-2 weeks only? (Two ideas are temporarily increasing estrogen and deoxycholic acid, could this produce the desired effect and are there any others ideas?)
5. Which beneficial microorganisms might be harmed by a temporarily heightened immune system (1-2 weeks) and which have clearly evolved to not be targeted by the immune system?
6. What's the general chain of events were the immune system to be aggravated for a 1 or 2 week period. The before, during, immediately after and a few weeks or months after? (Regarding things like cell damage, harm to beneficial microorganisms, any sickness or negative side effects of a heightened immune system developing etc. I have basic background knowledge, I know general symptoms of an allergic response such as spots developing on the body and such, I know cortisol and histamine are antagonists hence corticosteroids may be used to treat an allergic reaction etc. I'd like to know a little more in detail regarding if we were to stimulate an immune response on purpose in a controlled setting what might the biggest concerns be and how might we overcome or limit some of them)
7. Besides the medications commonly used for an outbreak of toxoplasmosis, what are some of the hypothetical ideas to kill toxoplasma cysts which are currently being researched or spoken about?
8. As a method of trying to eliminate toxoplasma cysts could we introduce the proteins secreted by non-latent toxoplasma, in order to promote Cytotoxic CD8 T-Cell release, which will then go on to destroy latent toxoplasma (cysts)?
Edited by argananana, 17 October 2019 - 06:31 PM.