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Effects And Methods Of Temporarily Stimulating The Immune System To Increase T-Cell Activation


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#1 argananana

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Posted 17 October 2019 - 06:27 PM

Hello All.  Hoping that there's anyone who knows a little something about this topic.  Perhaps some people in here have conducted research on immunostimulators.  This isn't my field of expertise but I need to learn more about a few things so any advice or guidance will be really appreciated.  
 

1. I need to know a little more about how specific or non specific Cytotoxic CD8 T-Cell receptors are.  For example if your body has a latent pathogen such as latent TB or toxoplasma cysts the immune system is no longer trying to fight them as they're effectively hiding from it.  Upon detection of a new pathogen such as a HIV infection the immune system will be activated.  It will release, amongst many immune cells, Cytotoxic CD8 T-Cells.  The T-Cells will recognise HIV as its antigen.  Will the immune system release Cytotoxic CD8 T-Cells which are only capable of fighting HIV infected cells as this is the pathogen which has currently stimulated it?  Or will the CD8 T-Cells which are released upon detection of HIV also be capable of killing cells infected by other pathogens including latent infections if they come into contact with them?  Also can this vary?  Are there instances where more generalised or a more diverse spread of Cytotoxic CD8 T-Cells are released and other instances where more specialised Cytotoxic CD8 T-Cells are released?  If so what are some factors which determine this?    

 

2.  What effect does purposely stimulating the immune system by exposure to an allergen have on the production and release of Cytotoxic CD8 T-Cells and what’s the effect (if any) of this increased activation of the immune system on internal pathogens in general and also specifically on toxoplasma cysts?  

 

3. What’s the effect (if any) of pure isolated oral histidine consumption on histamine levels, the subsequent effect on the immune system and on the production and release of Cytotoxic CD8 T-Cells? 

 

4.  Besides perfecting the diet and lifestyle such as correcting Vitamin A deficiencies, what are some ways to purposely induce an immune response and increase production and release of Cytotoxic CD8 T-Cells for a limited time such as for 1-2 weeks only?  (Two ideas are temporarily increasing estrogen and deoxycholic acid, could this produce the desired effect and are there any others ideas?)

 

5.  Which beneficial microorganisms might be harmed by a temporarily heightened immune system (1-2 weeks) and which have clearly evolved to not be targeted by the immune system?
  
6. What's the general chain of events were the immune system to be aggravated for a 1 or 2 week period.  The before, during, immediately after and a few weeks or months after?  (Regarding things like cell damage, harm to beneficial microorganisms, any sickness or negative side effects of a heightened immune system developing etc.  I have basic background knowledge, I know general symptoms of an allergic response such as spots developing on the body and such, I know cortisol and histamine are antagonists hence corticosteroids may be used to treat an allergic reaction etc.  I'd like to know a little more in detail regarding if we were to stimulate an immune response on purpose in a controlled setting what might the biggest concerns be and how might we overcome or limit some of them)  

7.  Besides the medications commonly used for an outbreak of toxoplasmosis, what are some of the hypothetical ideas to kill toxoplasma cysts which are currently being researched or spoken about? 

 

8. As a method of trying to eliminate toxoplasma cysts could we introduce the proteins secreted by non-latent toxoplasma, in order to promote Cytotoxic CD8 T-Cell release, which will then go on to destroy latent toxoplasma (cysts)?  


Edited by argananana, 17 October 2019 - 06:31 PM.


#2 VictorMedvil

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Posted 19 October 2019 - 02:10 AM

Ya, I had typed answers to this thread several days ago but my internet died and I lost all that data, I will again when I get time. Remember you are asking for a literal book on this subject. I usually answer the biology questions.


Edited by VictorMedvil, 19 October 2019 - 02:14 AM.


#3 VictorMedvil

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Posted 19 October 2019 - 02:51 AM

Hello All.  Hoping that there's anyone who knows a little something about this topic.  Perhaps some people in here have conducted research on immunostimulators.  This isn't my field of expertise but I need to learn more about a few things so any advice or guidance will be really appreciated.  
 

1. I need to know a little more about how specific or non specific Cytotoxic CD8 T-Cell receptors are.  For example if your body has a latent pathogen such as latent TB or toxoplasma cysts the immune system is no longer trying to fight them as they're effectively hiding from it.  Upon detection of a new pathogen such as a HIV infection the immune system will be activated.  It will release, amongst many immune cells, Cytotoxic CD8 T-Cells.  The T-Cells will recognise HIV as its antigen.  Will the immune system release Cytotoxic CD8 T-Cells which are only capable of fighting HIV infected cells as this is the pathogen which has currently stimulated it?  Or will the CD8 T-Cells which are released upon detection of HIV also be capable of killing cells infected by other pathogens including latent infections if they come into contact with them?  Also can this vary?  Are there instances where more generalised or a more diverse spread of Cytotoxic CD8 T-Cells are released and other instances where more specialised Cytotoxic CD8 T-Cells are released?  If so what are some factors which determine this?    

 

2.  What effect does purposely stimulating the immune system by exposure to an allergen have on the production and release of Cytotoxic CD8 T-Cells and what’s the effect (if any) of this increased activation of the immune system on internal pathogens in general and also specifically on toxoplasma cysts?  

 

3. What’s the effect (if any) of pure isolated oral histidine consumption on histamine levels, the subsequent effect on the immune system and on the production and release of Cytotoxic CD8 T-Cells? 

 

4.  Besides perfecting the diet and lifestyle such as correcting Vitamin A deficiencies, what are some ways to purposely induce an immune response and increase production and release of Cytotoxic CD8 T-Cells for a limited time such as for 1-2 weeks only?  (Two ideas are temporarily increasing estrogen and deoxycholic acid, could this produce the desired effect and are there any others ideas?)

 

5.  Which beneficial microorganisms might be harmed by a temporarily heightened immune system (1-2 weeks) and which have clearly evolved to not be targeted by the immune system?
  
6. What's the general chain of events were the immune system to be aggravated for a 1 or 2 week period.  The before, during, immediately after and a few weeks or months after?  (Regarding things like cell damage, harm to beneficial microorganisms, any sickness or negative side effects of a heightened immune system developing etc.  I have basic background knowledge, I know general symptoms of an allergic response such as spots developing on the body and such, I know cortisol and histamine are antagonists hence corticosteroids may be used to treat an allergic reaction etc.  I'd like to know a little more in detail regarding if we were to stimulate an immune response on purpose in a controlled setting what might the biggest concerns be and how might we overcome or limit some of them)  

7.  Besides the medications commonly used for an outbreak of toxoplasmosis, what are some of the hypothetical ideas to kill toxoplasma cysts which are currently being researched or spoken about? 

 

8. As a method of trying to eliminate toxoplasma cysts could we introduce the proteins secreted by non-latent toxoplasma, in order to promote Cytotoxic CD8 T-Cell release, which will then go on to destroy latent toxoplasma (cysts)?  

 

1.  Basically this CD8 Receptors are very non specific they will attack any cell that they see as a threat if the antigen for HIV-1 is detected, Cytotoxic cells that target all pathogens will be created as CD8 receptor stimulation deals in the proliferation of the Natural Killer Cells, if there is a memory cell active with the glycoproteins for targeting the TB antigen  then the Natural Killer Cells will also target the TB infection as the cells will be changed by the memory cell to attack the TB as well, but generally CD8 just making more of the natural killer cells as like a activation switch for increased immuno-activity in the area of detection making memory and natural killer cells to combat the threat. The Younger the person is the less glycoproteins that memory cells have as there have been less infectious agents that the younger person has been infected with, thus the memory cells will not have a glycoprotein for most pathogens. The amount of previous infects greatly changes immune response due to memory cells have been attuned to these pathogens and knowing how to defeat them.

 

2.  exposure to a allergen will increase the amount of immune system cells that are present at a location as they use Swarm Intelligence to combat infections thus if you exposured an area to a allergen there would be increased response in that location and varies surrounding locations.

 

3. I don't know the answer to this question, I would think Histidine would have no effect as that is used in DNA synthesis and cellular metabolism but would not effect the immune system maybe slightly.

 

4. Vaccination to the pathogen with either a Pseudotyped or weakened agent will usually begin the creation of antibodies and memory cells to combat the pathogen in question.

 

5. Any Beneficial pathogen could be targeted if the memory cells have a glycoprotein for the beneficial pathogen.

 

6. Natural Killer production and Memory Cells production then the immune system will begin to hunt the pathogens in the location of the initial simulation and also to a lesser extent throughout the entire body.

 

7. I don't know much about toxoplasmosis myself, but I am certain a properly made Viral Vector could defeat the disease on the genetic level or make a vaccine against the pathogen with the proper pseudo-typing and or genetic recombination. 

 

8. Yes generally vaccines do this to defeat pathogens by simulating the memory cell creation to make natural killer cells attuned to killing a disease, I don't think toxoplasmosis  would be any different. They did this same process with ebola antibodies in the ebola cure.

 

All this to say you need to make a vaccine against toxoplasmosis if you hope to destroy it before it becomes a problem, this is why children are given vaccines against pathogens to make them naturally immune by attuning the immune system against the pathogen. This is also why after you get chickenpox once usually you are immune to chickenpox for life, unless it mutates to shingles in which case the immune system is not attuned to the mutated form.


Edited by VictorMedvil, 19 October 2019 - 03:13 AM.


#4 argananana

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Posted 19 October 2019 - 04:11 PM

Ya, I had typed answers to this thread several days ago but my internet died and I lost all that data, I will again when I get time. Remember you are asking for a literal book on this subject. I usually answer the biology questions.


Haha I guess so. The amount I've asked.. it's up to me to learn more by myself right! I'm so sorry you lost all you wrote and thanks so much for taking the time to write it out again

#5 argananana

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Posted 19 October 2019 - 04:25 PM

1. Basically this CD8 Receptors are very non specific they will attack any cell that they see as a threat if the antigen for HIV-1 is detected, Cytotoxic cells that target all pathogens will be created as CD8 receptor stimulation deals in the proliferation of the Natural Killer Cells, if there is a memory cell active with the glycoproteins for targeting the TB antigen then the Natural Killer Cells will also target the TB infection as the cells will be changed by the memory cell to attack the TB as well, but generally CD8 just making more of the natural killer cells as like a activation switch for increased immuno-activity in the area of detection making memory and natural killer cells to combat the threat. The Younger the person is the less glycoproteins that memory cells have as there have been less infectious agents that the younger person has been infected with, thus the memory cells will not have a glycoprotein for most pathogens. The amount of previous infects greatly changes immune response due to memory cells have been attuned to these pathogens and knowing how to defeat them.

2. exposure to a allergen will increase the amount of immune system cells that are present at a location as they use Swarm Intelligence to combat infections thus if you exposured an area to a allergen there would be increased response in that location and varies surrounding locations.

3. I don't know the answer to this question, I would think Histidine would have no effect as that is used in DNA synthesis and cellular metabolism but would not effect the immune system maybe slightly.

4. Vaccination to the pathogen with either a Pseudotyped or weakened agent will usually begin the creation of antibodies and memory cells to combat the pathogen in question.

5. Any Beneficial pathogen could be targeted if the memory cells have a glycoprotein for the beneficial pathogen.

6. Natural Killer production and Memory Cells production then the immune system will begin to hunt the pathogens in the location of the initial simulation and also to a lesser extent throughout the entire body.

7. I don't know much about toxoplasmosis myself, but I am certain a properly made Viral Vector could defeat the disease on the genetic level or make a vaccine against the pathogen with the proper pseudo-typing and or genetic recombination.

8. Yes generally vaccines do this to defeat pathogens by simulating the memory cell creation to make natural killer cells attuned to killing a disease, I don't think toxoplasmosis would be any different. They did this same process with ebola antibodies in the ebola cure.

All this to say you need to make a vaccine against toxoplasmosis if you hope to destroy it before it becomes a problem, this is why children are given vaccines against pathogens to make them naturally immune by attuning the immune system against the pathogen. This is also why after you get chickenpox once usually you are immune to chickenpox for life, unless it mutates to shingles in which case the immune system is not attuned to the mutated form.

So your answer for 1. Is very interesting as it's what I wanted to know. Our immune system remembers past infections and will make T-Cells capable of fighting things we've previously been exposed to. In the case of toxoplasma our immune system fights this then it goes to a dormant stage where it forms cysts. The immune system stops detecting it so stops sending T-Cells to fight it. But if we then become infected with something else now these latent toxoplasma cysts can also be targeted by the T-Cells sent to deal with this new threat as the immune system remembers fighting it before. Exactly what I wanted to know. Thank you.

As for the rest you've given me some things to think about. I'm sure a vaccination against latent toxoplasma cysts is possible to create, to stimulate T-Cells to hunt them down. But we just put up with having them and many other latent pathogens in our system instead of trying to cure them as they're latent so we just ignore them..

As you said the immune system mostly tries to send cells to combat the pathogen in the area it's detected.. so I do wonder about for example how increased estrogen may affect this.. maybe it will give more of a general effect over the entire body or maybe the effect will be more specific to a certain area I'll have to try to find out more. Whilst exposure to an allergen e.g. pollen through the nose I wonder where these immune cells will be most active.

As for the amino acid histidine I know it's the precursor to histamine, our body uses histidine to create its own histamine. Histidine deficiency would then surely lead to low histamine levels. Whereas taking pure isolated histidine powder might boost histamine levels. Though I'm sure the body might tightly regulate histamine levels regardless how how much histamine is consumed. But then again consuming a pure isolated amino acid is unnatural and may spike levels as compared to eating amino acids from food sources. So I wondered maybe it'd increase histamine by an amount. Other amino acid precursors do boost their end product e.g. L-DOPA boosts dopamine 5-htp boosts serotonin so I thought histidine may boost histamine, then again maybe it won't by that much maybe the body too tightly regulates it. And if it does boost histamine levels what's the effect.. more immune cells throughout the body? I don't know! I'll have to try to find out more about this when I get the chance to do a lot of reading and try to find research studies which have tried giving histidine in trials.

The thing I'm interested in is activating T-Cells once again in order for them to find and destroy pathogens in general and also latent pathogens which they once fought but then stopped detecting as they went dormant e.g. formed cysts and so stopped fighting.

I had an idea to stimulate the immune system in general regularly, such as for 1 or 2 weeks yearly for this purpose. Sort of like an attempt at a general cleanse of the system/clearing out stuff the immune system has missed whether it be latent TB latent Toxoplasma etc


Again thanks a lot for your answers I'm going to try and read more into this.

Edited by argananana, 19 October 2019 - 04:32 PM.


#6 argananana

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Posted 19 October 2019 - 04:36 PM

Also from what I gather so far it seems like getting a cold regularly as most people do yearly may actually be a benefit to us as the T-Cells produced might kill some other pathogens in the system too. That might act like this yearly clear out of the system I had imagined. Really interesting.