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Obesity: Why are we getting fat? :epizza:


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Chili peppers deliver red hot weight control potential

By Shane Starling, 19-Mar-2009

 

Related topics: Industry, Antioxidants, carotenoids, Phytochemicals, plant extracts, Weight management

 

Carotenoid specialist, OmniActive Health Technologies, is moving ahead with its chili extract preliminary research indicates can burn 278 calories more than placebo in exercising subjects before, with dietary supplements manufacturers coming on board.

The Indian company that has done most of its business in lutein and curcumin, presented its Capsimax-branded chili extract at Expo West in Anaheim recently, where it noted a growing body of science backing the thermogenic potential of chili extracts – i.e. the ability to increase metabolic and calorie-burn rates.

Chili peppers deliver red hot weight control potential

 

 

Grape polyphenols may protect against obesity: Study

By Stephen Daniells, 18-Mar-2009

 

Related topics: Research, Antioxidants, carotenoids, Phytochemicals, plant extracts, Weight management

 

Antioxidant-rich supplements containing polyphenols from Chardonnay grape seed may protect against oxidative stress linked to obesity, suggests a new study with hamsters.

Researchers from the University of Montpellier report that animals fed a high-fat diet but supplemented with the grape seed extract had adiponectin levels 61 per cent higher than animals only fed the high fat diet. Adiponectin is a protein hormone linked to various metabolic processes, and levels are inversely related to body fat levels.

Grape polyphenols may protect against obesity: Study

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Fat Factors

 

By ROBIN MARANTZ HENIG

Published: August 13, 2006NYT

In the 30-plus years that Richard Atkinson has been studying obesity, he has always maintained that overeating doesn’t really explain it all. His epiphany came early in his career, when he was a medical fellow at U.C.L.A. engaged in a study of people who weighed more than 300 pounds and had come in for obesity surgery.

“The general thought at the time was that fat people ate too much,” Atkinson, now at Virginia Commonwealth University, told me recently. “And we documented that fat people do eat too much — our subjects ate an average of 6,700 calories a day.

But what was so impressive to me was the fact that not all fat people eat too much.

http://www.nytimes.com/2006/08/13/magazine/13obesity.html?_r=1&scp=6&sq=Robin+Marantz+Henig&st=nyt

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Overweight seniors live longer

Monday, 01 February 2010

University of Western Australia

Adding weight to calls for BMI revision
Related areas

Stories

* Study proves that older adults are mentally tough

* Dementia carers sought for research into Alzheimer's

* A new approach to treating childhood obesity

* Lifestyle changes prevent Alzheimer's disease

* Liver disease linked to increased diabetes risk

 

 

It may be timely to review the body mass index (BMI) classification for older adults as new research suggests that older overweight people are less likely to die over a 10 year period than their normal weight peers.

 

A statistical measurement which utilises a person's height and weight, the BMI has long been used as a formula by the World Health Organization to enable health professionals to discuss weight problems objectively with their patients.

 

However, a decade-long research project led by Winthrop Professor Leon Flicker at The University of Western Australia found that the category of overweight based on the index may not be a useful tool for Australian men and women aged between 70 and 75.

 

Professor Flicker and his team assessed 9,200 men and women for their health and lifestyle as part of a study into healthy ageing. They found that adults aged over 70 years who are classified as overweight are less likely to die than adults in the normal weight range. The researchers also found that this holds true for the common causes of death including both cancer and cardiovascular disease; and that being sedentary doubles the risk of death for women but only increases the risk by a quarter in men.

 

Published in the Journal of the American Geriatrics Society, the study sheds light on the situation in Australia, ranked the third most obese country after the United States and the United Kingdom.

 

These results add evidence to the claims that the WHO's BMI thresholds for overweight and obese are overly restrictive for older people. However, the benefits were only seen in the overweight category and not in those people who are obese. This research found that the same was true for men and women.

 

"The study shows that those people who survive to age 70 in reasonable health (and hence participate in these studies) have a different set of risks and benefits associated with the amount of body fat compared with younger people," Professor Flicker said.

 

"Concerns had been raised about encouraging overweight older people to lose weight and the object of our study was to examine the major unresolved question of ‘what level of BMI is associated with the lowest mortality risk in this group?'"

 

This study is published in the February issue of the Journal of the American Geriatrics Society. Media wishing to receive a PDF of this article may contact [email protected]

 

Full citation: Flicker L, McCaul KA, Hankey GJ, Jamrozik K., Brown WJ, Byles JE, Almeida OP; Body Mass Index and Survival in Older Men and Women Aged 70 to 75 Years; The Journal of the American Geriatrics Society (2009); DOI: 0.1111/j.1532-5415.2009.02677.x

 

About the Author: Leon Flicker, MB BS, PhD, FRACP, is based at the Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, The University of Western Australia. He is a Professor of Geriatric Medicine at UWA, a Consultant Geriatrician at Royal Perth Hospital and Director of the Western Australian Centre for Health and Ageing.

 

About the Journal: The Journal of the American Geriatrics Society is a comprehensive and reliable source of monthly research and information about common diseases and disorders of older adults. The journal is published by Wiley-Blackwell on behalf of the American Geriatrics Society. For more information, please visit Journal of the American Geriatrics Society - Journal Information.

Adding weight to calls for BMI revision | University News : University News : The University of Western Australia

Callooh! Callay! frabjous day!

 

Overweight seniors live longer (Science Alert)

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Childhood obesity: Genetic variation could be a factor

12. March 2010 08:56

 

More complicated

 

Increasing childhood obesity has worried governments and public health advisers in many countries. But a study of 300 children with severe obesity by the University of Cambridge and the Wellcome Trust Sanger Institute, suggest the problem may be more complicated than simply bad diet, overeating, or lack of exercise.

 

'It's a tricky issue,' says Doctor Matt Hurles from the Sanger Institute, 'because you don't want to remove peoples' motivation for their own health benefits. Equally, you don't want people to be stigmatized for things that are beyond their control.' Dr Hurles' group have been studying how the DNA structure, or the genome structure, varies between individuals, and the impact that has on health and disease. His team collaborated with a group specifically working on severe childhood obesity and they were keen to discover whether genetic variation could be a factor in obesity.

Childhood obesity: Genetic variation could be a factor

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Insufficient Sleep Associated With Overweight And Obesity

 

ScienceDaily (Jan. 20, 2005) — CHICAGO – Obese and overweight patients in a study group reported sleeping less than their peers with normal body mass indexes (BMIs), according to an article in the January 10 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

 

Insufficient sleep causes neurocognitive changes

Insufficient Sleep Associated With Overweight And Obesity

Race And Short Sleep Duration Increase The Risk For Obesity

 

ScienceDaily (June 8, 2009) — According to a research abstract that will be presented on June 8, at Sleep 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies, race significantly influences the risk of obesity conferred by short sleep duration, with blacks having a greater risk than whites.

Obesity Associated With Depression and Vice Versa

 

ScienceDaily (Mar. 2, 2010) — Obesity appears to be associated with an increased risk of depression, and depression also appears associated with an increased risk of developing obesity, according to a meta-analysis of previously published studies in the March issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Obesity associated with depression and vice versa
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Nonalcoholic fatty liver disease

 

Nonalcoholic fatty liver disease is a term used to describe the accumulation of fat in the liver of people who drink little or no alcohol.

 

Nonalcoholic fatty liver disease is common and, for most people, causes no signs and symptoms and no complications. But in some people with nonalcoholic fatty liver disease, the fat that accumulates can cause inflammation and scarring in the liver. This more serious form of nonalcoholic fatty liver disease is sometimes called nonalcoholic steatohepatitis. At its most severe, nonalcoholic fatty liver disease can progress to liver failure.

Nonalcoholic fatty liver disease - MayoClinic.com

Causes and Risk Factors of Fatty Liver

  1. Alcohol,
  2. obesity,
  3. starvation,
  4. diabetes mellitus,
  5. corticosteroids,
  6. poisons (carbon tetrachloride and yellow phosphorus),
  7. Cushing's syndrome, and hyperlipidemia are some causes of fatty liver.
  8. Microvesicular fatty liver may be caused by valproic acid

toxicity and high-dose tetracycline or during pregnancy.

Fatty Liver - Symptoms, Treatment and Prevention

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Zyprexa

Atypical antipsychotics in general have been linked to increasing the risk of
  • obesity,
  • weight gain,
  • high cholesterol, as well as
  • diabetes and
  • hyperglycemia

in schizophrenia patients who take these drugs.

Zyprexa Settlement and Seeger Weiss LLP

 

On June 7, 2005, Eli Lilly and Christopher Seeger of Seeger Weiss LLP, on behalf of the Plaintiff's Steering Committee in the federal Zyprexa MDL, announced a $700 million settlement. This settlement consists of approximately 8,000 cases against Eli Lilly, dealing with allegations that the atypical anti-psychotic drug Zyprexa caused patients to develop diabetes and diabetes-related injuries.

Zyprexa: Lawyer Seek Litigation - Pharmaceutical Injury (diabetes)

Sales of Zyprexa in 2008 were $2.2B in the US alone, and $4.7B in total.[4]

-wiki

The Food and Drug Administration requires all atypical antipsychotics to include a warning about the risk of developing hyperglycemia and diabetes, both of which are factors in the metabolic syndrome.

Not a warning on the Australian packets!

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Does starvation predispose to obesity?

NEJM -- Neuroendocrine Responses to Starvation and Weight Loss

 

How we’ve come to believe that overeating causes obesity

Decades of sound studies have continued to show that healthy obese people eat and behave no differently than anyone else to explain why their bodies are bigger.

 

It’s not “overeating,” or eating “unhealthy” foods or not enough “healthy” foods, or too little activity, that explains why some of us are fat and others lean.

Junkfood Science: How we’ve come to believe that overeating causes obesity

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For the time being I have absolutely nothing scientific to contribute to this topic, simply because I'm too lazy to form a coherent response.

 

However, I did find this following prayer amusing:

 

God grant me the serenity

To make good food choices;

Courage to turn away from baked goods;

And energy to exercise daily.

Living healthy one day at a time;

Enjoying my journey;

Accepting that the road to wellness can be hard;

Taking the tools of better eating out into the world

As I should, free from the bad habits of the past;

Trusting that making wise decisions today will pay off tomorrow;

If I surrender to my will

I will not beat myself up in this life and the next

But I will remember that this is a life long journey;

A journey that is well worth every pound lost.

 

Maybe tomorrow I'll care about how pudgy I'm getting :shrug:

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As a side thought.....maybe it's apathy that is making us fat

 

if you mean folks couldn't care less about cooking when they have the means to head for a trough at micky d's, then i agree it's apathy :lol: seems we americanos aren't the only plumpies now either. :read:

 

In China people getting fat fast, 200m overweight, 60m obese

In China people are getting fat fast' date=' says a new survey - 22.8% of the country's population are overweight while 7.1% are obese. Over 200 million are overweight and approvximately 60 million are obese.

 

In urban areas the rate is rocketing. In urban China 30% are overweight while 12.3% are obese. Health officials say that children in urban China are becoming obese at an alarming rate. At the moment 8.1% of Chinese kids are obese.

 

Wang Longde, Vice-minister of Health, said overweight and obesity rates are expected to grow by a large margin in the near future. [/quote']

 

 

McDonald's has a big appetite for China - CNBC TV- msnbc.com

McDonald's has a big appetite for China

BEIJING - Two decades ago, McDonald's was largely unknown here, except as a symbol of the decadent west. But a capitalist revolution has swept through the People's Republic. And today mainland China, still officially Communist, is home to 800 McDonald's restaurants — with 200 more in Hong Kong.

 

Jeff Schwartz, CEO of McDonald's China, says that’s just the beginning.

 

“I just look at China's 1.3 billion population,” he said. “U.S. (population) 300 million, 13,000 restaurants. China (population) 1.3 billion and 800 restaurants. Easily we're talking 10,000 to 5,000 restaurants as it continues to develop. So the opportunity is endless.”

 

good grief. :doh:

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Plastics... and other unusual explanations for the obesity epidemic

by Brie Cadman

Plastics... and other unusual explanations for the obesity epidemic

 

  • Adenovirus-36 (Ad-36)-almost 30 percent of obese people have antibodies (an indicator of exposure) to Ad-36, whereas only 5 percent of non-obese people have them
  • The Bacterial Bulge-Viruses aren't the only microbes that might play a role in obesity. It's no surprise that microorganisms, which exist in greater numbers in and on our bodies than our own cells, may also alter how we extract energy from food.
  • estrogen-mimicking chemicals, which are found in everything from shampoo to plastic water bottles.Known as obesogens, these foreign chemicals are thought to disrupt normal developmental control over energy balance and fat storage.

  • melanocortin-4 receptor-Null mutations of the melanocortin-4 receptor (MC4-R) are associated with hyperphagia, obesity, and
  • MC3-Receptor another central melanocortin receptor, the MC3-R. mice, while not significantly overweight, exhibit an approximately 50% to 60% increase in adipose mass

A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse -- Butler et al. 141 (9): 3518 -- Endocrinology

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Survival advantages of obesity in dialysis patients

In the general population, a high body mass index (BMI; in kg/m2) is associated with increased cardiovascular disease and all-cause mortality. However, the effect of overweight (BMI: 25–30) or obesity (BMI: >30) in patients with chronic kidney disease (CKD) undergoing maintenance hemodialysis (MHD) is paradoxically in the opposite direction; ie, a high BMI is associated with improved survival.

Survival advantages of obesity in dialysis patients -- Kalantar-Zadeh et al. 81 (3): 543 -- American Journal of Clinical Nutrition

 

Results of experimental studies suggest that deviations in gut microbiota composition predispose to excessive energy storage and obesity. The mother influences the original inoculum and the development of infant microbiota, which in turn is associated with later weight gain.

. . .

Bacteroides and Staphylococcus were significantly higher in the overweight state than in normal-weight women as assessed by FCM-FISH and qPCR. Mother's weight and BMI before pregnancy correlated with higher concentrations of Bacteroides, Clostridium, and Staphylococcus. Microbial counts increased from the first to third trimester of pregnancy. High Bacteroides concentrations were associated with excessive weight gain over pregnancy (P = 0.014).

 

Conclusions: Gut microbiota composition and weight are linked, and mother's weight gain is affected by microbiota. Microbiota modification before and during pregnancy may offer new directions for preventive and therapeutic applications in reducing the risk of overweight and obesity.

 

Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women -- Collado et al. 88 (4): 894 -- American Journal of Clinical Nutrition

 

Acute partial sleep deprivation increases food intake in healthy men

Conclusions: One night of reduced sleep subsequently increased food intake and, to a lesser extent, estimated physical activity–related energy expenditure in healthy men. These experimental results, if confirmed by long-term energy balance measurements, suggest that sleep restriction could be a factor that promotes obesity. This trial was registered at clinicaltrials.gov as NCT00986492.

http://www.ajcn.org/cgi/content/abstract/91/6/1550?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=obesity+unusual+cause*&searchid=1&FIRSTINDEX=40&resourcetype=HWCIT

 

Sugar and body weight regulation

 

JO Hill and AM Prentice

University of Colorado Health Science Center, Denver, USA.

 

The need to understand reasons for the high prevalence of obesity in developed countries has led to examination of dietary habits that may contribute to obesity. We consider whether consumption of high amounts of sugars presents a public health problem by contributing to the development of obesity. Metabolic studies show that diets high in fat are more likely to result in body fat accumulation than are diets high in carbohydrate. There is no indication that simple sugars differ from complex sugars in this regard. Epidemiologic data show a clear inverse relation between intake of sugar and fat. Further, although high intake of dietary fat is positively associated with indexes of obesity, high intake of sugar is negatively associated with indexes of obesity. There is ample reason to associate high-fat diets with obesity but, at present, no reason to associate high-sugar diets with obesity.

http://www.ajcn.org/cgi/content/abstract/62/1/264S?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=obesity+unusual+cause*&searchid=1&FIRSTINDEX=40&resourcetype=HWCIT

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Re- defining obesity?

Adding weight to calls for BMI revision

 

Thursday, 28 January 2010

 

It may be timely to review the body mass index (BMI) classification for older adults as new research suggests that older overweight people are less likely to die over a 10 year period than their normal weight peers.

 

A statistical measurement which utilises a person's height and weight, the BMI has long been used as a formula by the World Health Organization to enable health professionals to discuss weight problems objectively with their patients.

 

However, a decade-long research project led by Winthrop Professor Leon Flicker at The University of Western Australia found that the category of overweight based on the index may not be a useful tool for Australian men and women aged between 70 and 75.

 

Professor Flicker and his team assessed 9,200 men and women for their health and lifestyle as part of a study into healthy ageing. They found that adults aged over 70 years who are classified as overweight are less likely to die than adults in the normal weight range. The researchers also found that this holds true for the common causes of death including both cancer and cardiovascular disease; and that being sedentary doubles the risk of death for women but only increases the risk by a quarter in men.

 

Published in the Journal of the American Geriatrics Society, the study sheds light on the situation in Australia, ranked the third most obese country after the United States and the United Kingdom.

 

These results add evidence to the claims that the WHO's BMI thresholds for overweight and obese are overly restrictive for older people. However, the benefits were only seen in the overweight category and not in those people who are obese. This research found that the same was true for men and women.

Adding weight to calls for BMI revision | University News : University News : The University of Western Australia
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Here are a couple of things to consider - are wild animals fat? What about domesticated animals and civilized humans?

 

Could it be that it is this civilization that is the cause in two major ways?

 

Firstly, we use manpower less and machinery more than even fifty years ago. People use to walk - now they take taxis, buses, trains and drive their own personal vehicles, even to go a few hundred yards down the street. A job once done by a team of men is now done by one person with mechanical assistance. Animals that would have run for miles or scoured over a large area, are now restricted to pens, paddocks and sheds. All of this makes us and our livestock less exercised.

 

Then there is what we imbibe - not only the food we eat but the air we breathe and the liquids we drink, which all draw pollutants into our systems, either accidentally or deliberately (industrial by products or additives). Then there is all the imported foods, spices, supplements etc. (Again our ancestors would have been restricted to local forms of sustenance and even recent agricultural advances have caused intolerances and allergies, in the form of wheat and diary products). The Pima Indians are known to have reacted badly to this change of diet by putting on weight, so why not the rest of the Western World, especially coupled with restricted exercise as per modern man? (Combined diet/ mobility cause).

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Interesting theory.

Wild Animals rarely eat everday either-at least the carnivores- even at Zoos they starve them at least one day aweek to simulate the feat/famine cycle they normally have in the wild.

 

 

Access

 

To read this article in full you may need to log in, make a payment or gain access through a site license (see right).

nature.com > Journal home > Table of Contents

Article

 

European Journal of Human Genetics , (30 June 2010) | doi:10.1038/ejhg.2010.102

 

 

 

Paternally inherited microdeletion at 15q11.2 confirms a significant role for the SNORD116 C/D box snoRNA cluster in Prader–Willi syndrome

 

Angela L Duker, Blake C Ballif, Erawati V Bawle, Richard E Person, Sangeetha Mahadevan, Sarah Alliman, Regina Thompson, Ryan Traylor, Bassem A Bejjani, Lisa G Shaffer, Jill A Rosenfeld, Allen N Lamb and Trilochan Sahoo

Abstract

 

Prader–Willi syndrome (PWS) is a neurobehavioral disorder manifested by infantile hypotonia and feeding difficulties in infancy, followed by morbid obesity secondary to hyperphagia. It is caused by deficiency of paternally expressed transcript(s) within the human chromosome region 15q11.2

Access : Paternally inherited microdeletion at 15q11.2 confirms a significant role for the SNORD116 C|[sol]|D box snoRNA cluster in Prader|[ndash]|Willi syndrome : European Journal of Human Genetics

 

 

The research led them to con-

clude that there were two major

receptors: CB(1), found mainly in the

central nervous system and responsi-

ble for the psychotropic effects of

marijuana, spinal anesthesia.

By the way, a recent paper in the

International Journal of Obesity

studied the use of taranabant,

a CB(1) antagonist, as a weight loss

aid. (16 Feb 2010 [epub].) The paper

reported that groups on varying doses

of taranabant lost more weight than

controls. Unfortunately, the study had

to be stopped because of dose-related

adverse effects,son Center.

 

 

Special Report: Coming Soon to an ED Near You: Bromo-Dragonf... : Emergency Medicine News

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