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  1. It's my understanding that through the process of class switch recombination, loci fragments are lost in the plasma cell's genome. Does this mean that reversion to a prior isotype cannot be achieved and that isotype switching is always a linear progression within the differentiated cell? "While class switch recombination is mostly a deletional process, rearranging a chromosome in "cis", it can also occur (in 10 to 20% of cases, depending upon the Ig class) as an inter-chromosomal translocation mixing immunoglobulin heavy chain genes from both alleles." (https://www.wikiwand.com/en/Immunoglob
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