The development and change of the biome does NOT automatically imply "accumulation of pathogens".
Can you refer me to a link that supports the idea that the human body accumulates pathogens?
My needle of my crank detector has moved from its end stop.
You seem like you're in fact one of the uneducated moderators of the immunology section. Do you even have a PHD and work in immunology research?
I think that you don't have enough education or knowledge to have or deserve a "crank detector" because you don't know anything to know if something even begins to sound correct or not.
It sounds to me like someone told you we have a magical thing called a microbiome and this makes us immune to all disease. The reality is that microbiome is merely a word for all the microorganisms which live on and inside us. In reality we have an incredibly diverse range of different organisms living on and inside us. Some beneficial and some not so beneficial and this is also constantly changing. Tomorrow some species which live on you might die out and you might get a few different ones living on you. That's the reality. The microbiome isn't a magical thing which gives you immunity to all pathogens. The microbiome is just the name for small things which settle on us. Many of them in fact act like parasites and don't have a positive effect. Anything which gives any kind of negative effect whether spots, rash, dry flaky skin, stuffy nose, whatever, it can be called a pathogen. Many of them give mild negative effects but not strong enough for us to seriously pursue or use a cure: we just put up with them living on us. We can collect a new organism which comes to live on or inside us at any stage in our lives from exposure to it in the environment. All of the microorgsnisms out there which produce negative effects and which are quite successful at settling on or inside us and surviving we can easily contract from exposure and they may well live on/inside us for life. Hence we accumulate them over our lifetime. This is a basic fact.
examples of some of the pathogens we may contract, adding to the overall accumulation of many pathogens over our lifetimes are:
Herpes type 1 found in: 0% of newborns, 27% of 14-19 year olds, 41.3% of 20-29 year olds, 51.4% of 30-39 year olds, 59.7% of 40-49 year olds. (study on US citizens)
toxoplasma antibodies (which indicate the subject was once infected and hence latent cysts may be present) found in: 0% of newborns, 16% of 15-19 year olds, 27% of 20-24 year olds, 33% of 25-29 year olds, 40% of 30-34 year olds and over 50% of 35yrs+ (study on US females)
latent TB: found in 0% of newborns, 28% of 5-10 year olds, 88% of 31-35 year olds. (study on South Africans)
there are countless other pathogens which enjoy to live on us (really countless as many are yet to be discovered or studied in depth and they haven't all been clearly logged yet, is it in the hundreds of thousands or millions or trillions we are yet to know). some other common ones are fungal skin infections which are a main cause of dandruff, athlete's foot, can be a main cause of spots or blemishes on the skin etc.
these are just a few examples I cannot list every single pathogen out there for you.
Instead of asking for research papers maybe you should ask your teacher in class. This is a bit beneath research papers it's highschool text book level knowledge.
Funnily enough, not only did the uneducated mods not understand this. The guy who was moderating the immunology section, who wrongfully claimed humans don't accumulate pathogens over their lifetime, also claimed it's wrong, dangerous and a bad idea to try to stimulate the immune system. So it seems he's an antivaxer as well. Hilarious. An antivaxer who doesn't understand basic things about microorganisms moderating the immunology section and claiming I don't know what I'm talking about, moving my thread to speculations then locking it because their fragile egos couldn't take someone telling them they're wrong.
Edited by argananana, 18 October 2019 - 06:46 PM.